San Francisco 49ers vs. Jacksonville Jaguars: Spread Analysis, Pick Prediction

The NFL is back in London, and the 49ers bring winning runs of 6-1 SU and ATS as the road chalk into this game. Travel can be taken into consideration and coupled with the fact the Niners have stayed under in eight of their last 11 before a bye week.

Point spread: The game has remained off the board through Wednesday. (Line updates and Matchup report)

Computer Prediction: 25.5-3.0 49ers

Why the 49ers can cover the spread

Since losing two in a row, the def...

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