San Francisco 49ers vs Green Bay Packers: Betting Odds Preview, Prediction

The San Francisco 49ers beat Green Bay in last year's season-opener as a six-point road underdog, and the Packers look to return the favor Sunday as a 4.5-point pup.

Four months after that Week 1 win, San Francisco advanced in the playoffs with a 45-31 wild win at home over the Pack. Quarterback Colin Kaepernick rushed for 181 yards—an NFL playoff record for a quarterback—to lead a 579-yard attack as San Fran covered the three-point spread.

San Francisco is laying 4.5 points in this year's debut, Bleacher Report - San Francisco 49ers
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