San Francisco 49ers vs. Buffalo Bills: Full Report Card Grades for 49ers

The losing streak continues for the San Francisco 49ers despite making a quarterback change. A team that hasn't won since Week 1, the 49ers found themselves once again on the losing end against the Buffalo Bills in a 45-16 defeat. 

49ers quarterback Colin Kaepernick provided an early first-half spark but was unable to maintain that consistent play in the second half. Combine that effort with a struggling 49ers defense unable to stop the run, and you have a recipe for a blowout. 

Bleacher Report - San Francisco 49ers
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